10-Deacetylbaccatin III

10-Deacetylbaccatin III (CAS No.: 32981-86-5)

10-Deacetylbaccatins (10-DAB) (10-DAB) are a group of naturally occurring organic substances that were discovered in the Himalayan Region & Pacific Region as well (Taxus Wallichiana) and related species. The northern hemisphere’s temperate zones are home to Taxus baccata, or the European yew, while Nepal is home to Taxus Wallichiana. A biochemical step in the biosynthesis of the taxane paclitaxel is 10-DAB III. Taxanes are diterpenes that are frequently used for chemotherapeutic drugs. They are generated by plants of the genus Taxus (yews).

The principal mechanism of action of the taxane class of drugs is the disruption of microtubule function. Microtubules are essential to cell division, and taxanes stabilize GDP-bound tubulin in the microtubule, thereby inhibiting the process of cell division — a “frozen mitosis”. Thus, in essence, taxanes are mitotic inhibitors. Taxanes are also thought to be radiosensitizing. In addition, the esterification of 10-DAB III causes an enhancement in the kinetics, and in the pharmacological profile of important chemo-therapeutic agents such as Paclitaxel and docetaxel.

Application:
Taxanes are currently being investigated as possible treatment for certain cancers, and paclitaxel, is approved for treatment of AIDS-related Karposi sarcoma, breast cancer, non-small cell lung cancer, and ovarian.

Synonyms:
DESACETYLBACCATINE;BACCATIN III, 10-DEACETYL-;10-O-DEACETYLBACCATIN III;10-DAB-III;10-DEACETYLBACCATIN;12b-(Acetyloxy)-12-(benzoyloxy)-1,2a,3,4,4a,6,9,10,11,12,12a,12b-dodecahydro-4,6,9,11-tetrahydroxy-4a,8,13,13-tetramethyl-7,11-methano-5H-cyclodeca[3,4]benz[1,2-b]oxet-5-one;10-deacetylbaccatin11;10-deacetylbaccatiniii(extaxusbaccata), 10-Deacetylbaccatin III (CAS No.: 32981-86-5)

Molecular Formula: C29H36O10
Molecular Weight: 544.59
Manufacturer Specifications: Available upon request
Packing: Export Worthy
COA : Available upon request